Autism and Neurodevelopmental Disorders Clinical Trials and Research

Raising a child with autism spectrum disorder (ASD) can be challenging and rewarding. To support families and patients on this journey, the autism research program at CHOC is here to bring hope through new possibilities. We specialize in cutting-edge clinical trials and studies focused on discovering innovative methods for diagnosis, treatments, therapies and interventions for children with neurodevelopmental disorders. Our dedicated team of researchers and physicians want to help kids with ASD and their families live happier, healthier lives.

Our industry-leading autism research is part of the Thompson Autism and Neurodevelopmental Center at CHOC, which offers an array of unique programs, treatments, events, resources, education and more for families in the ASD community of Orange County. The center provides a trusted place where children with autism can reach their true potential.

Why should my child join an autism research study?

Autism research for children is needed to improve opportunities for those with ASD-related neurodevelopmental issues. CHOC works with children with ASD to collect firsthand data that helps us to better understand these conditions. With no two cases alike, the information gained from your child’s experience can support the development of life-changing treatments and therapies for your child and potentially for families worldwide.

Current Clinical Trials for Autism, Fragile X and Other Neurodevelopmental Disorders

We are regularly seeking patients to participate in our clinical trials. We regularly open new clinical trial opportunities, so please check back here for updates or subscribe to our autism newsletter.

We are currently recruiting patients for the following trials related to autism at CHOC:

• A 12-Week Crossover Study to Assess the Efficacy, Safety and Tolerability of L1-79 in Subjects Aged 12-21 Years With Autism Spectrum Disorder
• Study of Cariprazine Oral Capsules or Solution to Assess Adverse Events and Change in Irritability Due to Autism Spectrum Disorder (ASD) in Participants Aged 5-17 Years With ASD
• Open-Label, Flexible-dose Study to Evaluate the Long-Term Safety and Tolerability of Cariprazine in the Treatment of Pediatric Participants With Schizophrenia, Bipolar I Disorder, or Autism Spectrum Disorder
• Virtual Reality Training for Individuals with Autism Spectrum Disorder to Safely Respond to Law Enforcement

We are currently recruiting patients for the following trials related to Fragile X at CHOC:

• Clinical Study of Cannabidiol in Children, Adolescents, and Young Adults With Fragile X Syndrome
• Open Label Extension to Assess the Long-term Safety and Tolerability of ZYN002 in Children and Adolescents With FXS
• A Randomized Study of BPN14770 in Male Adolescents (Aged 12 to < 18 Years) With Fragile X Syndrome
• A Study of BPN14770 in Male Adults (Aged 18 to 45) With Fragile X Syndrome
• An Open-Label Extension Study of BPN14770 in Subjects With Fragile X Syndrome
• Characterizing the Natural History of Fragile X Syndrome to Inform the Development of Intervention Outcome Measures

Upcoming Autism Research Programs

We will soon be recruiting for the following clinical trials:

• Suramin for the Treatment of Autism Trial (STAT): A Randomized, Double-Blind, Crossover Trial of KZ101 in a Male Pediatric Population with Autism Spectrum Disorder
• Using real-time skin conductance to predict problem behavior before it occurs in autism spectrum disorder