Dr. Daniel W. Shrey, Neurology

Dr. Daniel W. Shrey, Neurology

  • Daniel W Shrey MD
  • Appointments:
  • Office: 714-509-7601
  • Specialties: Child Neurology, Clinical Neurophysiology
  • Board Certified: Child Neurology, Clinical Neurophysiology, Epilepsy

As a pediatric epilepsy specialist, Dr. Daniel Shrey primarily evaluates and cares for children with seizures, particularly refractory seizures (ones which medications fail to adequately control). His clinical interests include infantile spasms, Lennox-Gastaut syndrome, epilepsy surgery and quality improvement.

Dr. Shrey is also a nationally recognized leader in pediatric epilepsy research. In collaboration with his wife, Dr. Beth Lopour (biomedical engineering faculty at UC Irvine), his research leverages computational methods to analyze brain recordings in order to better understand epileptic disorders, such as infantile spasms and Lennox-Gastaut syndrome. He has collaborated with many regional research groups, including UCLA, UC Irvine, UCSF, Stanford and others. He led the Pediatric Epilepsy Research Consortium’s Infantile Spasms Group from 2020 to 2022, and he is the principal investigator for a 21-center nationwide study of infantile spasms funded by the Pediatric Epilepsy Research Foundation and a CHOC Chief Scientific Officer Award.

Dr. Shrey’s research has been funded by the NIH National Institute of Neurological Disorders and Stroke (NIH-NINDS), Pediatric Epilepsy Research Foundation, Lennox-Gastaut Syndrome Foundation, Elerding Foundation, UC Irvine Institute for Clinical and Translational Science, CHOC PSF Tithe Fund, CHOC Research Institute Physician-Scientist Scholars Award and CHOC Chief Scientific Officer Grant Program.

Locally, Dr. Shrey has contributed to multiple technological advances at CHOC that have improved the standard of care for children with epilepsy. These have included neuroimaging techniques, such as PET-MRI fusion, three dimensional CT and MRI reconstruction, and intracranial electrode localization for epilepsy surgery planning. Further, he implemented the collection of high frequency neurophysiological brain recordings in neonates, infants with infantile spasms, and epilepsy surgery patients at CHOC.

Dr. Shrey holds a bachelor’s degree in biomedical engineering from Northwestern University and earned his medical degree from the University of Cincinnati College of Medicine. He completed his pediatrics and child neurology residencies at UCLA. He also completed a subspecialty fellowship in pediatric clinical neurophysiology with a focus on pediatric epilepsy at CHOC and UC Irvine. He has been a practicing epilepsy specialist since 2014. He is a member of the Gold Humanism Honor Society, the American Epilepsy Society, the American Academy of Neurology, the American Academy of Pediatrics, the American Clinical Neurophysiology Society and the Orange County Medical Association. He was inducted as a fellow of the American Epilepsy Society in 2021 for his contributions to the field of pediatric epilepsy, and he has been named a Physician of Excellence in Orange County since 2019.

Daniel W Shrey MD is on staff at CHOC Hospital in Orange and CHOC Mission Hospital.


CHOC Neuroscience Center
505 S Main St, Suite 350
Orange, CA 92868
phone: 888-770-2462
fax: 855-246-2329


  • Medical School
    University of Cincinnati College of Medicine, Cincinnati, OH
  • Pediatrics Residency
    UCLA Ronald Reagan Medical Center, Los Angeles, CA
  • Child Neurology Residency
    UCLA Ronald Reagan Medical Center, Los Angeles, CA
  • Clinical Neurophysiology Fellowship
    UCI Medical Center, Orange, CA

Academic Appointments

  • Assistant Clinical Professor, UC Irvine

Administrative Appointments

  • Neurology, CHOC Specialists

Honors and Awards

  • American Epilepsy Society Epilepsy Fellow Scholarship Award
  • UCLA Division of Stroke Neurology Roger Bannister Award
  • UCLA Star Award of Excellence

Professional Organizations

  • American Academy of Neurology
  • American Epilepsy Society
  • Child Neurology Society
  • Infantile Spasms Consortium
  • Pediatric Epilepsy Research Consortium


  • Shrey DW, Kim McManus O, Rajaraman R, Ombao H, Hussain SA, Lopour BA. Strength and stability of EEG functional connectivity predict treatment response in infants with epileptic spasms. Clin Neurophysiol. 2018 Aug 4;129(10):2137-2148. doi: 10.1016/j.clinph.2018.07.017. PMID: 30114662.
  • Smith RJ, Sugijoto A, Rismanchi N, Hussain SA, Shrey DW, Lopour BA. Long-Range Temporal Correlations Reflect Treatment Response in the Electroencephalogram of Patients with Infantile Spasms. Brain Topogr. 2017 Nov;30(6):810-821. doi: 10.1007/s10548-017-0588-5. Epub 2017 Sep 13.
  • Shrey DW, Griesbach GS, Giza CC. The pathophysiology of concussions in youth. Phys Med Rehabil Clin N Am. 2011 Nov;22(4):577-602, vii. doi: 10.1016/j.pmr.2011.08.002. Epub 2011 Sep 25. Review. PMID: 22050937
  • Zupanc ML, Lily T, Mower AI, Taraman S, Shrey D, Steenari MR, Olaya J. Cost Effectiveness of Multidisciplinary Team Approach in Intractable Epilepsy Patients. Abstract. Annual American Epilepsy Society Meeting. December 2014.
  • Zupanc ML, Lily T, Mower AI, Shrey D, Steenari MR, Olaya J. Cost Effectiveness of Multidisciplinary Team Approach in Intractable Epilepsy Patients. Abstract Poster. Annual International Epilepsy Symposia. 2014.
  • Shrey DW, Mayo MC, Giza CC. Pediatric vs. Adult Mild Traumatic Brain Injury. Oxford Handbook of Sports-Related Concussion. In preparation.

Research Projects

Quantitative Biomarkers of Hypsarrhythmia for the Diagnosis of Infantile Spasms
Collaboration pilot grant by CHOC Research Foundation & UC Irvine

Our neurologists commonly treat:

More from Dr. Shrey

CHOC leads 21-center study to find predictive biomarkers for infantile spasms, a rare and dangerous type of epileptic seizure

NIH grant aims to locate high-frequency oscillations to reduce pediatric seizures

Leading-edge biomarker research aids in infantile spasms management