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Dr. Maria Gnarra Buethe, Division Chief of Dermatology, Director of Pediatric Dermatology

Dr. Maria Gnarra Buethe, Division Chief of Dermatology, Director of Pediatric Dermatology
  • Maria G. Buethe MD, Ph.D
  • Appointments:
    714-509-7760
  • Specialty: Dermatology
  • Board Certified: Dermatology
  • Additional Languages: Italian

Dr. Maria G. Buethe is a Board-Certified Dermatologist specializing in Pediatric Dermatology. She brings a wealth of expertise and passion for treating children with rare and complex dermatologic conditions.

In addition to her role as Chief of the Pediatric Dermatology Division at Children’s Hospital of Orange County (CHOC), she also serves as the Director of Pediatric Dermatology at the University of California, Irvine.

Dr. Buethe holds a PhD in Pediatric Vascular Anomalies and has conducted pioneering research on infantile hemangiomas and vascular malformations at prestigious institutions including Great Ormond Street Hospital, University College of London, Boston Children’s Hospital, Harvard University and Columbia University. She is a recognized leader in the field and currently co-chairs the Society for Pediatric Dermatology’s Vascular Birthmarks section. In addition to vascular anomalies, Dr. Buethe has been actively involved in research in the field of genodermatoses and complex pediatric skin disorders.

Maria G. Buethe MD, Ph.D is on staff at CHOC Hospital in Orange .

Locations

CHOC Specialists, Dermatology
1201 W La Veta Avenue
Orange, CA 92868
phone: 7145097987
fax: 855-246-2329

Center for Advanced Care (Jamboree)
19200 Jamboree Rd., 2nd Floor
Irvine, CA 92612
phone: 7145097987
fax: 855-246-2329

Education

  • Medical School
    Universita Cattolica del Sacro Cuore, Rome, Italy
  • Pediatric Internship
    SUNY Downstate Health Science University, Brooklyn, NY
  • Dermatology Residency
    SUNY Downstate Health Science University, Brooklyn, NY
  • Pediatric & Adolescent Dermatology Fellowship
    Rady Children’s Hospital, University of California, San Diego, CA

Research Interests:

  • Vascular Anomalies
  • Genodermatosis/Rare skin disease

Publications:

1. Zaffanello M, Gnarra M, Buonsenso D, Cataldi L, Zaffanello M. Le infezioni delle vie urinary del neonato. Rivista di Infettivologia Neonatale 2010; anno III, numero 2: 19-23. Rivista di Infettivologia Neonatale. 2010, Jan; III(2): 19-23.

2. Zampetti A, Gnarra M, Linder D. Digiuseppe MD, Carrino N, Feliciani C. Psoriatic Pseudobalanitis Circinata as a Post-Viral Koebner Phenomenon. Case Rep Dermatology. 2010, Nov; 2(3): 183–188. Cited in PubMed; PMID: 21113343.

3. Cataldi L, Zaffanello M, Gnarra M, Fanos V. Urinary tract infection in the newborn and the infant: state of the art. The Journal of Maternal-Fetal & Neonatal Medicine. 2010, Oct; 23(Sup 3): 90-93. Cited in PubMed; PMID: 20883144.

4. Zampetti A, Gnarra M, Linder D, Antuzzi D, Cataldi L, Tulli A, Feliciani C. Early-onset basal cell carcinoma in a case of Ivemark syndrome. European Journal of Dermatology. 2010, Nov; 20(6): 845-6. Cited in PubMed; PMID: 20959271.

5. Zampetti A, Orteu CH, Antuzzi D, Bongiorno MR, Manco S, Gnarra M, Morrone A, Cardinali G, Kovacs D, Aspite N, Linder D, Parini R, Feliciani C. Angiokeratoma: decision-making aid for the diagnosis of Fabry disease. British Journal of Dermatology. 2012, Apr; 166(4): 712-720. Cited in PubMed; PMID: 22452439.

6. Zampetti A, Gnarra M, Borsini W, Giurdanella F, Antuzzi D, Piras A, Smaldone C, Pieroni M, Cadeddu C, de Waure C, Feliciani C. Vascular endothelial growth factor (VEGF-a) in Fabry disease: association with cutaneous and systemic manifestations with vascular involvement. Cytokine. 2013, Mar; 61(3): 933-939. Cited in PubMed; PMID: 23332617.

7. Murabit A, Gnarra M, Mohamed A. Reversed palmaris longus muscle: Anatomical variant – case report and literature review. Can Journal Plastic Surgery. 2013, Apr; 21(1): 55-56. Cited in PubMed; PMID: 24431941.

8. Murabit A, Gnarra M, O’Grady K, Morhart M. Olson JL. Functional outcome after the Hoffer procedure. Plastic Reconstrive Surgery. 2013, Jun; 131(6): 1300-6. Cited in PubMed; PMID: 23714791.

9. Zampetti A, Decinti MD, Gnarra M, Massi G, Feliciani C, Linder D. “Eczema-like” leishmaniasis in an HIV patient. European Journal of Dermatology. 2013, Jul; 23(4): 542-4. Cited in PubMed; PMID: 24004717.

10. Zampetti A, Giurdanella F, Manco S, Linder D, Gnarra M, Guerriero G, Feliciani C. Acquired epidermodysplasia verruciformis: a comprehensive review and a proposal for treatment. Dermatologic Surgery. 2013, Jul; 39(7): 974–980. Cited in PubMed; PMID: 23437916.

11. Gnarra M, Rotoli M, Fabrizi C, Pagliarello G, Feliciani C. Lipoatrophia semicircularis: a case report and review of the literature. Clinical Dermatology. 2013, Sep; 1(3): 146 – 148.

12. Zampetti A, Fania L, Antuzzi D, Giurdanella F, Gnarra M, Bertola F, Lualdi S, Filocamo M, Morrone A, Feliciani C. Mutation identification of Fabry disease in families with other lysosomal storage disorders. Clinical Genetics. 2013, Sep; 84(3): 281-5. Cited in PubMed; PMID: 23210910.

13. Gnarra M, Rotoli M, Giurdanella F, Fabrizi G, Feliciani C. Herpes Zoster in an immunocompetent child: a case-based review. Clinical Dermatology. 2013, Sep; 1(3): 153-155.

14. Giurdanella F, Fania L, Gnarra M, Toto. Di Rollo D, Sauder DN, Feliciani C. A possible role for CD8+ T lymphocytes in the cell-mediated pathogenesis of pemphigus vulgaris. Mediators of Inflammation. 2013, Nov; 2013(764290): 1-5. Cited in PubMed; PMID: 24347833.

15. Gnarra M, Saraceni P, Rossi A, Murabit A, Caradonna E, Fania L, Feliciani C. Challenging Diagnosis of Peripillous Sheaths. Pediatric Dermatology. 2014, Jul; 31(4): 112-3. Cited in PubMed; PMID: 24846654.

16. Gnarra M, Castriota, M. Rowland, S.P. Bonalumi G, Glieca, F., Feliciani, Claudio. (2014). A Case of Pyoderma Gangrenosum After Long Saphenous Vein Harvesting. EJVES Extra. 47. 10.1016/j.ejvsextra.2013.11.005.

17. Solman L. Murabit A. Gnarra M, Harper JI, Syed SB, Glover M. Propranolol for infantile haemangiomas: single centre experience of 250 cases and proposed therapeutic protocol. Archives of disease in childhood. 2014, Aug; 99(12): 1132–1136. Cited in PubMed; PMID: 25123404.

18. Concolino D, Degennaro R, Parini R. Fabry Delphi working group. Delphi consensus on the current clinical and therapeutic knowledge on Anderson-Fabry disease. European Journal of Internal Medicine. 2014, Oct; 25(8): 751-6. Cited in PubMed; PMID:25123424.

19. Tellkamp F, Benhadou F, Bremer J, Gnarra M, Knüver J, Schaffenrath S, Vorhagen S. Transgenic mouse technology in skin biology: generation of knocking mice. The Journal of Investigative Dermatology. 2014, Dec; 134(12): 1-3. Cited in PubMed; PMID: 25381772.

20. Gnarra M, Solman L, Harper J, Syed S. Propranolol and prednisolone combination for the treatment of segmental haemangioma in PHACES syndrome. The British journal of dermatology. 2015, Jul; 173(1): 242-6. Cited in PubMed; PMID: 25639889.

21. van der Zeeuw F, Murabit A, Volcano J, Torensma, Hay N, Thorburn G, Morris P, Sommerlad B, Gnarra M, van der Horst C, Kangesu L. A Reliable Method to Measure Lip Height Using Photogrammetry in Unilateral Cleft Lip Patients. The Journal of craniofacial surgery. 2015, Sep; 26(6): 1865-70. Cited in PubMed. PMID: 26147027

22. Shawber CJ, Lin L, Gnarra M, Sauer MV, Papaioannou VE, Kitajewski JK, Douglas NC. Vascular Notch proteins and Notch signaling in the peri-implantation mouse uterus. Vascular cell. 2015, Dec; 7(9): 1-17. Cited in PubMed; PMID: 26629328.

23. Garcovich S,* Gnarra M,* Murabit A, Arena V, Sani I, Feliciani C. First report of hereditary Christ-Siemens-Touraine syndrome and non-segmental vitiligo association in a young adult: contraindication for vitiligo treatment. Journal of the European Academy of Dermatology and Venereology. 2016, Feb; 30(2): 346-8. Cited in PubMed; PMID: 25339629.

24. Gnarra M, Behr G, Kitajewski A, Wu JK, Anupindi SA, Shawber CJ, Zavras N, Schizas D, Salakos C. Economopoulos KP. History of the infantile hepatic hemangioma: From imaging to generating a differential diagnosis. World Journal of Clinical Pediatrics. 2016, Aug; 5(3): 273-80. Cited in PubMed; PMID: 27610342.

25. Simoncini C, Chico L, Concolino D, Sestito S, Fancellu L, Boadu W, Sechi GP, Feliciani C, Gnarra M, Zampetti A, Salviati A, Scarpelli M, Orsucci D, Bonuccelli U, Siciliano G, Mancuso M. Mitochondrial DNA haplogroups may influence Fabry disease phenotype. Neuroscience Lett. 2016, Aug; 629(1): 58-61. Cited in PubMed; PMID: 27365132.

26. Petruzziello C, Sinatti D, Gnarra M, Migneco A, Tesori V, Graziani C, Gasbarrini A, Franceschi F, Ojetti V. May Gender or Ethnicity Affect Delta Over Baseline Values Obtained by 13-C Urea Breath Test? Reviews on Recent Clinical Trials. 2017, Jan; 12(3): 187 -192. Cited in PubMed; PMID: 28814259.

27. Bassi A,* Gnarra M,* Shaw L, Rampling D, Syed S. Inflammatory linear verrucous epidermal nevus: an unusual manifestation. G Ital di Dermatol Venereol. 2017, Feb; 152(1): 72-73. Cited in PubMed; PMID: 26426377.

28. Ojetti V, Petruzziello C, Migneco A, Gnarra M, Gasbarrini A, Franceschi F. Effect of Lactobacillus reuteri (DSM 17938) on methane production in patients affected by functional constipation: a retrospective study. European Review for Medical and Pharmacological Sciences. 2017, Apr; 21(7): 1702-1708. Cited in PubMed; PMID: 28429333.

29. Gnarra M, De Simone C. Garcovich M, Garcovich S. Low-Dose Cyclosporine A in the Treatment of Severe Atopic Dermatitis Complicated by Chronic Hepatitis C Virus Infection. Pediatric Dermatology. 2017, May; 34(3): 374-376. Cited in PubMed; PMID: 28382768.

30. Gnarra M, Murabit A. (2017, September 04). Concomitant Unusual Presentation of an Arteriovenous Malformation in a Mother and Child. https://doi.org/10.1177/2513826X17728266,

31. van Geel N, Boniface K, Seneschal J, Jacquemin C, Speeckaert R, Wolkerstorfer A, Bekkenk M, Lommerts JE, Hamzavi I, Pandya A, Eleftheriadou V, Ezzedine K, Giannarelli D, Gnarra M, Sperduti I, Prinsen C, Harris J, Taieb A, Picardo M. Meeting report: Vitiligo Global Issues Consensus Conference Workshop “Outcome measurement instruments” and Vitiligo International Symposium, Rome, Nov 30-Dec 3rd. Pigment Cell Melanoma Research. 2017, Jul; 30(4): 436-443. Cited in PubMed; PMID: 28379638.

32. van Geel N, Wolkerstorfer A. Ezzedine K, Pandya AG, Bekkenk M. Grine L, Van Belle S. Lommerts JE, Hamzavi I, Harris JE, Eleftheriadou V, Esmat S, Kang HY, Kumarasinghe P, Lan CE, Parsad D, Raboobee N, Flora Xiang L, Suzuki T Prinsen CA, Taieb A Pica. Validation of a physician global assessment tool for vitiligo extent: Results of an international vitiligo expert meeting. Pigment Cell Melanoma Res. 2019, Sep; 32(5): 728-733. Cited in PubMed; PMID: 30945409.

33. Muley A, Kim Uh M, Salazar-De Simone G, Swaminathan B, James JM, Murtomaki A, Youn SW, McCarron JD, Kitajewski C, Gnarra Buethe M, Riitano G, Mukouyama YS, Kitajewski J, Shawber CJ. Unique functions for Notch4 in murine embryonic lymphangiogenesis. Angiogenesis. 2021 Oct 19. doi: 10.1007/s10456-021-09822-5. Epub ahead of print. PMID: 34665379.

34. Nguyen JK, Buethe M, Siegel DM. “Balloon Glove” Technique: An Easy Alternative to Pressure Dressing for Postoperative Hemostasis. Dermatol Surg. 2022 Jan 19. doi: 10.1097/DSS.0000000000003385. PMID: 35066553.

35. Buethe MG, Bayliss SJ, Shmuylovich L. Venous Malformations: A Journey Through Their Multifaceted Clinical Presentations. Dermatol Clin. 2022 Oct;40(4):435-443. doi: 10.1016/j.det.2022.06.001. Epub 2022 Sep 16. PMID: 36243430

36. Burshtein J, Buethe M.G., Ghias M, MD, Stein A.B, Glick S, Marmon S. Efficacy, Perception, and Utilization of Pediatric Teledermatology: A Systematic Review. JAADI- Volume 12, P3-11, September 2023. DOI:https://doi.org/10.1016/j.jdin.2023.03.005

37. Burshtein, J., Gnarra Buethe, M. (2024). Artificial Intelligence in Dermatology: A Review of Literature and Application to Pediatric Dermatology. SKIN The Journal of Cutaneous Medicine, 8(1), 1250–1257. https://doi.org/10.25251/skin.8.1.5

38. Buethe MG, Di Franco A, Uwakwe L, Glick SA. Treatment of Infantile Hemangiomas in Concomitant Tuberous Sclerosis Complex Should Prompt Evaluation for Cardiac Rhabdomyomas Prior to Initiation of Propranolol. Cutis. 2024 Jun;113(6):E14-E16. doi: 10.12788/cutis.1040. PMID: 39082988.

39. Buethe MG, Kellogg C, Seo YJ, Vuong C, Eichenfield LF. Topical Therapy for Atopic Dermatitis: What is New and the New Paradigm. Dermatol Clin. 2024 Oct;42(4):569-575. doi: 10.1016/j.det.2024.05.001. Epub 2024 Jun 15. PMID: 39278710.

40. Chang H, Dykman M, Lara-Corrales I, Luu M, Wan J, Metry D, Buethe MG, et all. Highlights from the Field of Pediatric Dermatology Research from the 2023 PeDRA Annual Conference. Journal of Investigative Dermatology; JID-2024-0719.R1