Dr. William G. Loudon, Neurosurgery

For more than 25 years, Dr. William Loudon has provided comprehensive neurosurgical care to children and adults throughout Southern California. His philosophy of care extends beyond treating neurological disease alone-it is centered on caring for the whole person and supporting patients and their families through every stage of their medical journey. Dr. Loudon believes that exceptional neurosurgical care combines technical excellence with compassion, clear communication, and an enduring physician-patient relationship.

Dr. Loudon’s unique background reflects a non-traditional 21-year academic pathway that includes medical training at the University of Texas Health Science Center at Houston, graduate training culminating in a PhD in Tumor Biology at The University of Texas MD Anderson Cancer Center, a research fellowship at the National Institute of Neurological Disorders and Stroke (NINOS) in Bethesda, Maryland, neurosurgical residency training at the Medical College of Virginia, and fellowship training in Pediatric Neurosurgery at the Children’s Hospital of Philadelphia (CHOP).

Today, his practice blends this depth of academic expertise with the accessibility and personalized attention of private practice. He is committed to providing longitudinal, physician-led care that emphasizes thoughtful clinical judgment, multidisciplinary collaboration, and compassionate guidance for patients facing both routine and highly complex neurological conditions. Whether caring for a child with a congenital disorder, an adult with a brain or spine tumor, or a family navigating a life-altering diagnosis, Dr. Loudon strives to ensure that every patient feels heard, supported, and cared for with dignity, empathy, and unwavering commitment.

Locations

Comprehensive Neurological Associates
30131 Town Center Drive, #195
Laguna Niguel, CA 92677

Education

• Fellowship
  Pediatric neurosurgery fellowship at University of Pennsylvania/Children’s Hospital of Philadelphia, Philadelphia, PA
• Medical School
  University of Texas at Houston, TX
• Residency
  Pediatric neurosurgical residency at Medical College of Virginia, Richmond, VA

Honors and Awards

• Orange County Medical Association’s Physicians of Excellence 2010-2025

Publications

Oana M. Mereuta, Julien Ognard, Esref Bayraktar, Yasuhito Ueki, Daying Dai, Jack Weissberg, Suehyun Cho, Evaline Wang, Teresa Yuan, Anish Vaghela, Xiaobo Ma, Sarah Lortscher, Dan R. Montonye, Christopher K Gow, Edward Ahn, Waleed Brinjikji, Ramanathan Kadirvel, William G Loudon. Magnetically guided microrobot via minimally invasive percutaneous cisternal access: a first preclinical evaluation. J. Neurosurgery. 2026, In Press.

Shin B, Davies J, Self S, Salehi A, Skar G, McCulloh R, Olaya J, Yengo-Kahn A, Klugh A, Loudon W, Lai G. Safety and Feasibility of an Irrigating External Intracranial Drain in Children. J. Neurosurgery Pediatrics. DOI:10.3171/2025.9PEDS25294/ Jan 2026.

Fote GM, Schafenacker A, Singh J, Sherlock D, Romero B, Loudon WG, et al. Management of Positive Cerebrospinal Fluid Cultures from Intraventricular Reservoirs in Neuronal Ceroid Lipofuscinosis Type 2 Patients: One Institution’s Experience. J. Ped. Neurosurgery. 22:36(5)Nov 2025.

Loudon WG, Kardosh M, Cros F, Katznelson B, Shtein A, Fedotenko K, Castel D, Palmer OJ, Kiselyov A. Novel untethered micro-robotic platform developed for minimally invasive ultra-selective microsurgical procedures and targeted drug delivery: preliminary characterization of tissue response to intraparenchymal navigation in ovine brain. Surgical Neurology International. DOI:10.25259/SNI_841_2024. May 2025.

Heyming T, Knudsen-Robbins C, Schomberg J, Hayakawa J, Lara B, Bacon K, Valdez B, Wickens M, Shelton SK, Romain J, Wallace E. Evaluation of Quantitative Pupillometry in Acute Post-Injury Pediatric Concussion. Pediatric neurology. 2024 Jan 14.

Poceviciute R, Mitchell K, Nikolakopoulou AM, Cho SK, Ma X Chen P, Loudon WG, et al. Quantitative 3D reconstruction of viral vector distribution in rodent and ovine brain following local delivery. Neuroimage: Reports 4.4 2024

Xu, J. C., Vargas, A. J., Waunch, A., Gibbs, D. L., Cappon, J. P., Loudon, W. G., & Magge, S. N No more bull: pediatric head injuries as a result of mechanical bull rides. Child’s nervous system, 39(1), 1-4. 2023.

Liau, L. M., Ashkan, K., Brem, S., Campian, J. L., Trusheim, J. E., Iwamoto, F. M., … & Bosch, M. L. Association of autologous tumor lysate-loaded dendritic cell vaccination with extension of survival among patients with newly diagnosed and recurrent glioblastoma: a phase 3 prospective externally controlled cohort trial. JAMA Oncology, 9(1), 112-121. 2022 November 17.

Xu JC, Suzuki S, Chrislip J, Nael A, Loudon WG. Embolization of a third ventricular choroid plexus papilloma: illustrative case. J Neurosurg Case Lessons. 2022;3(5): CASE 21516. 2022 Jan 31.

Guner YS, Gibbs D, Duong WQ, Loudon W, et al. Analysis of unintentional falls in pediatric population and predictors of morbidity. Journal of Surgical Research, 267, 48-55. 2021 November.